| Time | Status | Match | FT | H1 | Stats |
| 18/03/2022 18:00 |
(FT) | Academico Viseu[15] Rio Ave[2] |
0 1 |
0 0 |
MF | ME |
| 19/03/2022 11:00 |
(FT) | SC Covilha[16] CD Mafra[8] |
2 0 |
0 0 |
MF | ME |
| 19/03/2022 14:00 |
(FT) | Penafiel[9] SC Farense[12] |
1 3 |
1 2 |
MF | ME |
| 20/03/2022 11:00 |
(FT) | CD Nacional[6] Academica Coimbra[18] |
3 1 |
1 0 |
MF | ME |
| 20/03/2022 14:00 |
(FT) | SL Benfica B[3] Leixoes[7] |
2 3 |
0 2 |
MF | ME |
| 20/03/2022 14:00 |
(FT) | Casa Pia Ac[1] Feirense[5] |
1 1 |
1 0 |
MF | ME |
| 20/03/2022 15:30 |
(FT) | Porto B[10] Amadora[11] |
2 2 |
2 1 |
MF | ME |
| 20/03/2022 18:00 |
(FT) | Clube Desportivo Trofense[14] Chaves[4] |
1 1 |
1 0 |
MF | ME |
| 20/03/2022 20:30 |
(FT) | Vilafranquense[13] Varzim[17] |
0 0 |
0 0 |
MF | ME |