| Time | Status | Match | FT | H1 | Stats |
| 22/10/2021 18:00 |
(FT) | Academico Viseu[12] Varzim[15] |
1 0 |
1 0 |
MF | ME |
| 22/10/2021 18:00 |
(FT) | Vilafranquense[16] Leixoes[10] |
1 3 |
0 1 |
MF | ME |
| 23/10/2021 11:00 |
(FT) | Penafiel[5] Rio Ave[2] |
1 1 |
0 1 |
MF | ME |
| 23/10/2021 14:00 |
(FT) | Casa Pia Ac[4] Chaves[6] |
1 0 |
1 0 |
MF | ME |
| 23/10/2021 15:30 |
(FT) | Porto B[13] SC Farense[17] |
0 0 |
0 0 |
MF | ME |
| 23/10/2021 18:00 |
(FT) | SL Benfica B[3] Academica Coimbra[18] |
3 1 |
2 1 |
MF | ME |
| 24/10/2021 11:00 |
(FT) | Feirense[1] Amadora[9] |
1 2 |
0 1 |
MF | ME |
| 24/10/2021 14:00 |
(FT) | CD Nacional[7] CD Mafra[8] |
1 1 |
0 0 |
MF | ME |
| 24/10/2021 19:30 |
(FT) | Clube Desportivo Trofense[14] SC Covilha[11] |
3 0 |
2 0 |
MF | ME |