| Time | Status | Match | FT | H1 | Stats |
| 05/11/2021 18:00 |
(FT) | Vilafranquense[15] Amadora[7] |
2 2 |
0 1 |
MF | ME |
| 06/11/2021 11:00 |
(FT) | Clube Desportivo Trofense[12] Rio Ave[4] |
0 1 |
0 1 |
MF | ME |
| 06/11/2021 14:00 |
(FT) | Casa Pia Ac[3] Academica Coimbra[18] |
2 0 |
1 0 |
MF | ME |
| 07/11/2021 11:00 |
(FT) | Penafiel[8] Leixoes[9] |
1 1 |
0 1 |
MF | ME |
| 07/11/2021 14:00 |
(FT) | SL Benfica B[1] CD Mafra[11] |
1 3 |
1 1 |
MF | ME |
| 07/11/2021 15:30 |
(FT) | Porto B[13] Varzim[17] |
2 2 |
1 0 |
MF | ME |
| 07/11/2021 19:30 |
(FT) | SC Covilha[14] SC Farense[16] |
0 0 |
0 0 |
MF | ME |
| 08/11/2021 18:00 |
(FT) | CD Nacional[6] Chaves[10] |
1 1 |
0 1 |
MF | ME |
| 08/11/2021 20:15 |
(FT) | Academico Viseu[5] Feirense[2] |
0 2 |
0 0 |
MF | ME |