| Time | Status | Match | FT | H1 | Stats |
| 22/01/2022 11:00 |
(FT) | Vilafranquense[14] CD Nacional[4] |
4 3 |
2 2 |
MF | ME |
| 22/01/2022 15:30 |
(FT) | Varzim[18] Academica Coimbra[17] |
1 0 |
0 0 |
MF | ME |
| 23/01/2022 11:00 |
(FT) | Feirense[3] CD Mafra[10] |
1 0 |
0 0 |
MF | ME |
| 23/01/2022 14:00 |
(FT) | Porto B[6] Casa Pia Ac[2] |
0 3 |
0 0 |
MF | ME |
| 23/01/2022 15:30 |
(FT) | Rio Ave[4] SC Farense[16] |
2 1 |
2 1 |
MF | ME |
| 23/01/2022 18:00 |
(FT) | SL Benfica B[1] Penafiel[7] |
1 0 |
0 0 |
MF | ME |
| 23/01/2022 19:30 |
(FT) | Amadora[9] Clube Desportivo Trofense[12] |
2 0 |
2 0 |
MF | ME |
| 24/01/2022 15:30 |
(FT) | Academico Viseu[13] SC Covilha[15] |
1 1 |
0 1 |
MF | ME |
| 24/01/2022 20:15 |
(FT) | Leixoes[11] Chaves[8] |
1 1 |
1 0 |
MF | ME |