| Time | Status | Match | FT | H1 | Stats |
| 23/04/2022 11:00 |
(FT) | Casa Pia Ac[2] Amadora[13] |
3 0 |
2 0 |
MF | ME |
| 23/04/2022 14:00 |
(FT) | Chaves[3] Academica Coimbra[18] |
3 2 |
3 0 |
MF | ME |
| 24/04/2022 11:00 |
(FT) | Penafiel[8] Feirense[4] |
2 0 |
1 0 |
MF | ME |
| 24/04/2022 14:00 |
(FT) | CD Mafra[10] Rio Ave[1] |
1 1 |
1 1 |
MF | ME |
| 24/04/2022 15:30 |
(FT) | SL Benfica B[5] Academico Viseu[14] |
1 2 |
0 2 |
MF | ME |
| 24/04/2022 15:30 |
(FT) | Porto B[11] Vilafranquense[12] |
0 1 |
0 1 |
MF | ME |
| 24/04/2022 15:30 |
(FT) | CD Nacional[6] SC Farense[9] |
3 2 |
1 1 |
MF | ME |
| 24/04/2022 16:59 |
(FT) | SC Covilha[16] Leixoes[7] |
1 1 |
1 0 |
MF | ME |
| 25/04/2022 15:30 |
(FT) | Clube Desportivo Trofense[17] Varzim[15] |
1 0 |
0 0 |
MF | ME |