| Time | Status | Match | FT | H1 | Stats |
| 21/08/2021 11:00 |
(FT) | Amadora[16] SC Farense[14] |
3 1 |
0 1 |
MF | ME |
| 21/08/2021 14:00 |
(FT) | Penafiel[9] Casa Pia Ac[5] |
1 0 |
1 0 |
MF | ME |
| 22/08/2021 11:00 |
(FT) | Varzim[12] Rio Ave[3] |
0 3 |
0 1 |
MF | ME |
| 22/08/2021 14:00 |
(FT) | Leixoes[4] Academica Coimbra[17] |
2 1 |
0 1 |
MF | ME |
| 22/08/2021 15:30 |
(FT) | Porto B[15] CD Nacional[10] |
1 1 |
1 0 |
MF | ME |
| 22/08/2021 18:00 |
(FT) | Academico Viseu[7] CD Mafra[6] |
1 3 |
0 2 |
MF | ME |
| 22/08/2021 18:00 |
(FT) | SL Benfica B[1] Clube Desportivo Trofense[13] |
2 1 |
2 0 |
MF | ME |
| 22/08/2021 19:30 |
(FT) | Feirense[8] Chaves[11] |
3 1 |
3 0 |
MF | ME |
| 23/08/2021 18:00 |
(FT) | Vilafranquense[18] SC Covilha[2] |
1 1 |
0 0 |
MF | ME |