| Time | Status | Match | FT | H1 | Stats |
| 17/09/2021 20:00 |
(FT) | Celta Vigo[18] Cadiz[16] |
1 2 |
0 2 |
MF | ME |
| 18/09/2021 13:00 |
(FT) | Rayo Vallecano[12] Getafe[19] |
3 0 |
1 0 |
MF | ME |
| 18/09/2021 15:15 |
(FT) | Atletico Madrid[3] Athletic Bilbao[5] |
0 0 |
0 0 |
MF | ME |
| 18/09/2021 17:30 |
(FT) | Elche[10] Levante[14] |
1 1 |
1 0 |
MF | ME |
| 18/09/2021 20:00 |
(FT) | Alaves[20] Osasuna[11] |
0 2 |
0 2 |
MF | ME |
| 19/09/2021 13:00 |
(FT) | Mallorca[8] Villarreal[13] |
0 0 |
0 0 |
MF | ME |
| 19/09/2021 15:15 |
(FT) | Real Sociedad[4] Sevilla[6] |
0 0 |
0 0 |
MF | ME |
| 19/09/2021 17:30 |
(FT) | Real Betis[9] Espanyol[15] |
2 2 |
2 1 |
MF | ME |
| 19/09/2021 20:00 |
(FT) | Valencia[2] Real Madrid[1] |
1 2 |
0 0 |
MF | ME |
| 20/09/2021 20:00 |
(FT) | Barcelona[7] Granada[17] |
1 1 |
0 1 |
MF | ME |