| Time | Status | Match | FT | H1 | Stats |
| 12/11/2021 19:45 |
(FT) | Edinburgh City[5] Stranraer[7] |
3 1 |
2 0 |
MF | ME |
| 13/11/2021 15:00 |
(FT) | Albion Rovers[7] Stirling Albion[3] |
1 0 |
1 0 |
MF | ME |
| 13/11/2021 15:00 |
(FT) | Elgin City[9] Cowdenbeath[10] |
1 0 |
0 0 |
MF | ME |
| 13/11/2021 15:00 |
(FT) | Kelty Hearts[1] Forfar Athletic[2] |
1 0 |
0 0 |
MF | ME |
| 13/11/2021 15:00 |
(FT) | Stenhousemuir[5] Annan Athletic[4] |
2 0 |
1 0 |
MF | ME |