| Score | Handicap | Over-under | 1x2 | |||||
| 25/04/2021 15:45 | FT | Feyenoord Rotterdam[5] Vitesse Arnhem[4] (Draw) | 0 0 | 0-0.5 | 0.96 0.94 | 2.75 u | 0.85 0.85 | 2.21 2.99 3.40 | 
| 25/04/2021 15:45 | FT | Twente Enschede[9] Utrecht[7] (Draw) | 1 2 | 0.25 | 1.01 0.79 | 2.75 u | 0.85 0.85 | 3.00 2.26 3.50 | 
| 25/04/2021 13:30 | FT | Ajax Amsterdam[1] AZ Alkmaar[3] (Draw) | 2 0 | 1 | 0.86 0.94 | 3 u | 0.73 0.97 | 1.49 5.95 4.70 | 
| 25/04/2021 13:30 | FT | ADO Den Haag[18] Fortuna Sittard[12] (Draw) | 0 3 | 0.5 | 0.99 0.81 | 2.75 u | 0.85 0.85 | 4.10 1.85 3.70 | 
| 25/04/2021 11:15 | FT | Emmen[17] Heracles Almelo[8] (Draw) | 3 1 | 0 | 0.88 0.92 | 2.5 u | 0.85 0.85 | 2.65 2.55 3.45 | 
| 24/04/2021 17:45 | FT | Sparta Rotterdam[11] VVV Venlo[16] (Draw) | 2 0 | 1 | 1.00 0.80 | 2.75 u | 0.90 0.80 | 1.63 5.40 3.90 | 
| 24/04/2021 17:45 | FT | PSV Eindhoven[2] Groningen[6] (Draw) | 1 0 | 1.5 | 0.96 0.84 | 2.75 u | 0.80 0.90 | 1.37 8.40 4.95 | 
| 24/04/2021 15:30 | FT | SC Heerenveen[10] Zwolle[13] (Draw) | 0 2 | 0.5 | 1.00 0.80 | 2.75 u | 0.85 0.85 | 2.03 3.45 3.70 | 
| 23/04/2021 17:45 | FT | Willem II[15] RKC Waalwijk[14] (Draw) | 1 0 | 0.5 | 1.00 0.90 | 2.5-3 u | 0.95 0.90 | 1.80 3.95 3.65 |