| Score | Handicap | Over-under | 1x2 | |||||
| 14/03/2021 15:45 | FT | Zwolle[13] Ajax Amsterdam[1] (Draw) | 0 2 | 1.75 | 0.97 0.83 | 3.5 u | 0.76 0.94 | 9.00 1.25 6.50 | 
| 14/03/2021 13:30 | FT | PSV Eindhoven[2] Feyenoord Rotterdam[5] (Draw) | 1 1 | 0.5 | 0.84 0.96 | 3 u | 0.73 0.97 | 1.76 4.25 3.95 | 
| 14/03/2021 13:30 | FT | Utrecht[7] Vitesse Arnhem[4] (Draw) | 1 3 | 0.5 | 0.97 0.93 | 2.75 u | 0.93 0.77 | 2.55 2.60 3.55 | 
| 14/03/2021 11:15 | FT | VVV Venlo[15] Fortuna Sittard[11] (Draw) | 1 3 | 0-0.5 | 0.98 0.92 | 2.75 u | 0.74 0.96 | 2.37 2.90 3.45 | 
| 13/03/2021 20:00 | FT | Sparta Rotterdam[12] RKC Waalwijk[14] (Draw) | 2 0 | 0.5 | 0.86 0.94 | 2.5-3 u | 1.06 0.82 | 1.82 4.25 3.70 | 
| 13/03/2021 19:00 | FT | Groningen[6] Emmen[18] (Draw) | 1 1 | 0.5 | 0.85 0.95 | 2.5 u | 0.90 0.80 | 1.51 6.40 4.25 | 
| 13/03/2021 19:00 | FT | AZ Alkmaar[3] Twente Enschede[8] (Draw) | 4 1 | 1.25 | 0.86 0.94 | 3 u | 0.86 0.84 | 1.38 7.85 4.90 | 
| 13/03/2021 17:45 | FT | ADO Den Haag[17] Heracles Almelo[10] (Draw) | 1 2 | 0.75 | 0.91 0.89 | 2.5 u | 1.03 0.88 | 3.55 1.98 3.70 | 
| 13/03/2021 15:30 | FT | Willem II[16] SC Heerenveen[9] (Draw) | 3 1 | 0.25 | 0.77 1.03 | 2.75 u | 0.84 0.86 | 2.75 2.25 3.50 |