| Time | Status | Match | FT | H1 | Stats |
| 16/10/2021 14:00 |
(FT) | Balzan[8] Floriana[5] |
1 2 |
0 1 |
MF | ME |
| 16/10/2021 16:00 |
(FT) | Hamrun Spartans[7] Gzira United[6] |
0 1 |
0 0 |
MF | ME |
| 16/10/2021 18:00 |
(FT) | Birkirkara FC[2] Gudja United[4] |
2 0 |
1 0 |
MF | ME |
| 17/10/2021 14:00 |
(FT) | Sliema Wanderers FC[12] Hibernians FC[1] |
0 3 |
0 1 |
MF | ME |
| 17/10/2021 16:00 |
(FT) | Valletta FC[9] Sirens[3] |
3 1 |
1 0 |
MF | ME |
| 17/10/2021 18:00 |
(FT) | Santa Lucia[10] Mosta[11] |
2 2 |
0 1 |
MF | ME |